Risk Factors Associated with the Activity and Severity of Graves’ Ophthalmopathy among Patients at the University of the Philippines Manila-Philippine General Hospital

Authors

Keywords:

Graves’ ophthalmopathy, Graves’ disease, thyrotropin receptor antibody

Abstract

*Visual Abstracts prepared by Dr. Carmen Carina Cabrera

Background. Asians with Graves’ ophthalmopathy (GO) may have earlier compressive features due to narrower orbital apex and increased orbital volume.

Objective. To determine the risk factors associated with activity and severity of GO among adults.

Methodology. This was a cross-sectional analytical study of 163 adults with Graves’ disease (GD) from the outpatient clinics of the Philippine General Hospital. Demographics, clinical data, thyrotropin receptor antibody (TRAb) and urine iodine (UIE) levels were obtained. All participants were evaluated for activity and severity of GO by a single ophthalmologist.

Results. The population was predominantly composed of females (81%) and nonsmokers (69%), with a mean age of 35 + 11 years and median GD duration of 2 years. Median TRAb was 8.9 U/L while UIE was 171 mcg/L. Eight percent exhibited active GO, with 85% having mild disease. Multivariate analysis showed male sex to be associated with severe disease (OR 3.71, p=0.041), while elevated TRAb was associated with both active (OR 1.03, p=0.002) and severe GO (OR 1.02, p=0.007).

Conclusion. Lower rates of active and severe GO were seen compared to previous reports. In this population of predominantly nonsmokers, elevated TRAb emerged as a risk factor for active and severe GO.

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Author Biographies

Annabelle Marie Lat, University of the Philippines - Philippine General Hospital

Section of Endocrinology Diabetes and Metabolism, Department of Medicine

Maria Cristina Jauculan, University of the Philippines-Philippine General Hospital

Section of Endocrinology Diabetes and Metabolism, Department of Medicine

Charisse Ann Sanchez, University of the Philippines-Philippine General Hospital

Section of Plastic-Lacrimal and Orbit, Department of Ophthalmology and Visual Sciences

Cecilia Jimeno, University of the Philippines-Philippine General Hospital

Section of Endocrinology Diabetes and Metabolism, Department of Medicine

Cherrie Mae Sison-Peña, University of the Philippines-Philippine General Hospital

Section of Endocrinology Diabetes and Metabolism, Department of Medicine

Mary Rose Pe-Yan, University of the Philippines-Philippine General Hospital

Section of Plastic-Lacrimal and Orbit, Department of Ophthalmology and Visual Sciences

Paulo Ma. Pagkatipunan, University of the Philippines-Philippine General Hospital

Section of Plastic-Lacrimal and Orbit, Department of Ophthalmology and Visual Sciences

Armida Suller, University of the Philippines-Philippine General Hospital

Section of Plastic-Lacrimal and Orbit, Department of Ophthalmology and Visual Sciences

Marianne Cena, University of the Philippines-Philippine General Hospital

Section of Plastic-Lacrimal and Orbit, Department of Ophthalmology and Visual Sciences

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Published

2017-09-06

How to Cite

Lat, A. M., Jauculan, M. C., Sanchez, C. A., Jimeno, C., Sison-Peña, C. M., Pe-Yan, M. R., Pagkatipunan, P. M., Suller, A., & Cena, M. (2017). Risk Factors Associated with the Activity and Severity of Graves’ Ophthalmopathy among Patients at the University of the Philippines Manila-Philippine General Hospital. Journal of the ASEAN Federation of Endocrine Societies, 32(2), 151. Retrieved from https://www.asean-endocrinejournal.org/index.php/JAFES/article/view/421

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