Successful Modified Desensitization Therapy with Analog Insulin in an Individual with Severe Allergy to Multiple Insulin Preparations: A Case Report

Wan Juani Wan Seman, Azraai Bahari Nasruddin, Nurain Mohd Noor


We present a case of a 27-year-old lady with T2 DM who developed allergic reactions after commencement of insulin therapy. Trial with different types of insulin resulted in a series of allergic reactions ranging from urticarial rash to development of angioedema, bronchospasm and anaphylactic shock. She was successfully treated with a modified insulin desensitization protocol using rapid-acting insulin.


insulin allergy, desensitization, excipients, T2 DM, insulin preparations

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