Case Report of Tumour-induced Osteomalacia with Parotid Gland Tumour as a Focus

Authors

  • Jyotsna Oak Kokilaben Dhirubhai Ambani Hospital, Mumbai
  • Girish Parmar Kokilaben Dhirubhai Ambani Hospital, Mumbai
  • Satish Sharma Kokilaben Dhirubhai Ambani Hospital, Mumbai
  • Bijal Kulkarni Kokilaben Dhirubhai Ambani Hospital, Mumbai
  • Laxmi Patil Kokilaben Dhirubhai Ambani Hospital, Mumbai

Keywords:

TIO, Hypophosphatemia, FGF-23

Abstract

Tumour-induced osteomalacia (TIO) is a rare paraneoplastic syndrome, which is characterized by overproduction of FGF23 as a phosphaturic agent leading to chronic phosphaturia and hypophosphatemia, associated with inappropriately normal or low levels of vitamin D. We describe a rare case of a 57-year-old Indian female who presented with bone pains, muscle pains and lower limb weakness. On examination she was found to have hypophosphatemia. Our work up led to the identification of a FGF23 secreting parotid tumour. The tumour responsible for symptoms was a pleomorphic adenoma of the parotid gland. Its complete resection resulted in normalisation of patient's symptoms. Laboratory parameters and microsopic examination further revealed a mesenchymal tumour of mixed connective tissue type.

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Author Biographies

Jyotsna Oak, Kokilaben Dhirubhai Ambani Hospital, Mumbai

Consultant Physician and Rheumatologist

Girish Parmar, Kokilaben Dhirubhai Ambani Hospital, Mumbai

Consultant Endocrinologist

Satish Sharma, Kokilaben Dhirubhai Ambani Hospital, Mumbai

Resident, Department of Medicine

Bijal Kulkarni, Kokilaben Dhirubhai Ambani Hospital, Mumbai

Consultant Pathologist

Laxmi Patil, Kokilaben Dhirubhai Ambani Hospital, Mumbai

Resident, Department of Medicine

References

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Published

2016-11-07

How to Cite

Oak, J., Parmar, G., Sharma, S., Kulkarni, B., & Patil, L. (2016). Case Report of Tumour-induced Osteomalacia with Parotid Gland Tumour as a Focus. Journal of the ASEAN Federation of Endocrine Societies, 31(2), 171. Retrieved from https://asean-endocrinejournal.org/index.php/JAFES/article/view/330

Issue

Section

Case Reports

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