Dermopathy, Acropachy and Orbitopathy in Graves’ Disease

James Young; Michael Villa

doi:10.15605/jafes.026.01.16

Authors

James Young Section of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, St. Luke’s Medical Center, Quezon City, Philippines
Michael Villa Section of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, St. Luke’s Medical Center, Quezon City, Philippines

DOI:

https://doi.org/10.15605/jafes.026.01.16

Keywords:

dermopathy, acropachy, orbitopathy, Graves’ Disease

Abstract

A 56-year-old Filipino male presented with bilateral lower limb swelling. The patient was a known smoker with a one-year history of Graves’ disease. He was initially treated with methimazole for control of thyrotoxicosis. Five months prior to consultation, he was given oral radioactive iodine (Iodine-131) for the definitive treatment of his thyroid disease.

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References

Bartalena L, Tanda ML. Clinical practice. Graves’ opthalmopathy. N Engl J Med. 2009;360(10):994-1001. PMID: 19264688. https://doi.org/10.1056/NEJMcp0806317.

Marino M, Chiovato L, Pinchera A. Graves’ Disease. In: Jameson JL, De Groot LJ, eds. Endocrinology Adult and Pediatric. 6th Edition. Philadelphia: Saunders; 2010:1527-71.

Davies TF, Larsen PR. Thyrotoxicosis. In: Kronenberg HM, Melmed S, Polonsky KS, Larsen PR, eds. Williams Textbook of Endocrinology. 11th Edition. Philadelphia: Saunders; 2008:333-75.

Fatourechi V, Pajouhi M, Fransway AF. Dermopathy of Graves’ disease (pretibial myxedema): Review of 150 cases. Medicine (Baltimore). 1994;73(1):1-7. PMID: 8309359.

Tiu SC, Choi CH. Elephantiasic thyroid dermopathy. Hong Kong Med J. 2006;12(2):159-60. PMID: 16603786.

Fatourechi V, Ahmed DD, Schwartz KM. Thyroid acropachy: Report of 40 patients treated at a single institution in a 26-year period. J Clin Endocrinol Metab. 2002;87:5435-41. PMID: 12466333. https://doi.org/10.1210/jc.2002-020746.

Anderson CK, Miller OF 3rd. Triad of exophthalmos, pretibial myxedema and acropachy in a patient with Graves’ disease. J Am Acad Dermatol 2003;48(6):970-2. PMID: 12789197. https://doi.org/10.1067/mjd.2003.323.

Bartalena L, Baldeschi L, Dickinson A, Eckstein A, Kendall-Taylor P, Marcocci C, et al. Consensus statement of the European Group on Graves’ orbitopathy (EUGOGO) on management of GO. Eur J Endocrinol. 2008;158(3):273–85. PMID: 18299459. https://doi.org/10.1530/EJE-07-0666

Dickinson J, Perros P. Thyroid-associated orbitopathy: Who and how to treat. Endocrinol Metab Clin North Am. 2009;38(2):373–88. PMID: 19328417. https://doi.org/10.1016/j.ecl.2009.01.004.

Antonelli A, Saracino A, Agostini S, Alberti B, Melosi A, Gambuzza C, et al. Results of high-dose intravenous immunoglobulin treatment of patients with pretibial myxedema and Basedow’s disease: Preliminary findings. Clin Ter. 1992;141(9 Pt 2):63-8. PMID: 1281765.