@article{Hamzah_Aman_Iskandar_2022, title={Fatal Case of Possible Thyroid Crisis Induced by SARS-CoV-2 Infection: A Case Report}, volume={37}, url={https://www.asean-endocrinejournal.org/index.php/JAFES/article/view/2171}, DOI={10.15605/jafes.037.02.19}, abstractNote={<p>Thyroid crisis is an emergency due to impaired thyroid function caused by various conditions, particularly infections such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that result in the dysfunction of various vital organs. We report a case of  a 31-year-old Indonesian female with a 2-year history of hyperthyroidism with elevated thyroid-stimulating hormone (TSH) receptor antibodies. (TRAb) who developed thyroid crisis possibly in association with SARS-CoV-2 pneumonia, sepsis, and disseminated intravascular coagulation (DIC). Prior to admission, she was treated for her hyperthyroidism with propylthiouracil and had been in stable remission for a year. She was admitted to the Emergency Room with complaints of watery stools, icteric sclerae, jaundice, coughing, and shortness of breath. The physical examination showed a World Health Organization (WHO) performance score of 4, delirium, blood pressure within normal limits, tachycardia, tachypnea, axillary temperature of 36.7°C, icteric sclerae, jaundice, and exophthalmos. There was a 3 cm palpable nodule on the right side of the neck. Auscultation  of the lungs revealed bilateral pulmonary rales. Abdominal examination noted a palpable liver and enlarged spleen.  Laboratory tests showed thrombocytopenia, electrolyte imbalance, hypoalbuminemia and elevated transaminases. The thyroid function tests showed a suppressed TSH level with an elevated free thyroxine (FT4) level. The SARS-CoV-2 polymerase chain reaction (PCR) swab test was positive. Initial patient management was with supportive therapy that included favipiravir and anti-hyperthyroidism medication; however, despite these interventions, her condition continued to deteriorate and she died after a few hours. This case demonstrates no difference in therapy between patients with thyroid crises and COVID-19 or other infections. Proper and timely treatment is important for reducing mortality rates.</p>}, number={2}, journal={Journal of the ASEAN Federation of Endocrine Societies}, author={Hamzah, Febriyani and Aman, Andi Makbul and Iskandar, Harun}, year={2022}, month={Nov.}, pages={101–105} }