TY - JOUR AU - Wong, Poh Shean AU - Lim, Sue Wen AU - Tong, Chin Voon AU - Mohamad, Masni AU - Hussein, Zanariah PY - 2022/09/05 Y2 - 2024/03/29 TI - Use of Combination of Oral Levothyroxine and Liothyronine in Severe Hypothyroidism With Massive Pericardial Effusion JF - Journal of the ASEAN Federation of Endocrine Societies JA - J ASEAN Fed Endocr Soc VL - 37 IS - 2 SE - Case Series DO - 10.15605/jafes.037.02.17 UR - https://www.asean-endocrinejournal.org/index.php/JAFES/article/view/1875 SP - 106-112 AB - <p>Thyroid hormone plays an important role in cardiovascular function. Pericardial effusions are commonly seen in cases of severe hypothyroidism. However, large to massive pericardial effusions with cardiac tamponade are exceptionally rare.</p><p>Herein, we present two cases of severe hypothyroidism with massive pericardial effusion. Our first case demonstrates that a patient with large pericardial effusion can be managed conservatively with aggressive thyroid hormone replacement therapy. In our second case,  pericardiocentesis was performed in addition to thyroid hormone replacement therapy as the underlying aetiology of effusion  could not be reasonably limited to hypothyroidism.</p><p>These two cases served to highlight and demonstrate rapid normalisation of thyroid function test by using aggressive oral thyroid hormone replacement therapy using liothyronine, in combination with levothyroxine, which led to resolution of pericardial effusion and prevent its re-accumulation.</p> ER -