TY - JOUR AU - Tan, Margarita Katrina Amor AU - Lim Alba, Rebecca AU - Li, Kingbherly PY - 2023/02/27 Y2 - 2024/03/29 TI - Association of Vitamin D levels on the Clinical Outcomes of Patients Hospitalized for COVID-19 in a Tertiary Hospital JF - Journal of the ASEAN Federation of Endocrine Societies JA - J ASEAN Fed Endocr Soc VL - 38 IS - 1 SE - Original Articles DO - 10.15605/jafes.038.01.07 UR - https://www.asean-endocrinejournal.org/index.php/JAFES/article/view/2437 SP - 81-89 AB - <p><strong>Objectives.</strong> This study aimed to compare the severity of COVID-19, inflammatory parameters and clinical outcomes among patients with normal and subnormal levels of Vitamin D.</p><p><strong>Methodology.</strong> This is a retrospective cohort study of 135 patients admitted in a tertiary hospital for COVID-19. Patients were grouped according to their Vitamin D level. Primary outcome measure was the composite of all-cause mortality and morbidity. Other outcome measures determined were the comparison among the groups on the severity of COVID-19 infection, changes in inflammatory parameters, length of hospital stay and duration of respiratory support.</p><p><strong>Results.</strong> There was a significant trend of higher ICU admission (p=0.024), mortality (p=0.006) and poor clinical outcome (p=0.009) among the Vitamin D deficient group. No significant difference was found for most of the inflammatory parameters, duration of hospital stay and respiratory support. Overall, patients with deficient, but not insufficient Vitamin D level had 6 times higher odds of composite poor outcome than those with normal Vitamin D (crude OR=5.18, p=0.003; adjusted OR=6.3, p=0.043).</p><p><strong>Conclusion.</strong> The inverse relationship between Vitamin D level and poor composite outcome observed in our study suggests that low Vitamin D may be a risk factor for poor prognosis among patients admitted for COVID-19.</p> ER -