TY - JOUR AU - Thewjitcharoen, Yotsapon AU - Yenseung, Nalin AU - Butadej, Siriwan AU - Nakasatien, Soontaree AU - Chotwanvirat, Phawinpon AU - Chatchomchuan, Waralee AU - Wanothayaroj, Ekgaluck AU - Krittiyawong, Sirinate AU - Himathongkam, Thep PY - 2023/03/02 Y2 - 2024/03/28 TI - Real-World Use of Once-Weekly Semaglutide in Thai Patients with Type 2 Diabetes Mellitus in a Private Hospital Setting JF - Journal of the ASEAN Federation of Endocrine Societies JA - J ASEAN Fed Endocr Soc VL - 38 IS - 1 SE - Original Articles DO - 10.15605/jafes.038.01.11 UR - https://www.asean-endocrinejournal.org/index.php/JAFES/article/view/2493 SP - 21-28 AB - <p><strong>Objective.</strong> To evaluate the real-world use of once-weekly semaglutide among Thai patients with type 2 diabetes (T2DM) in a private hospital setting.</p><p><strong>Methodology</strong>. A retrospective review of Thai patients with T2DM who have initiated semaglutide for at least 1 month between June 2020 and March 2022 at Theptarin Hospital, Bangkok, Thailand.</p><p><strong>Results.</strong> A total of 58 patients (50% female, mean age 55.6 ± 15.9 years, with duration of diabetes 12.6 ± 10.3 years, BMI 31.5 ± 4.4 kg/m<sup>2</sup>, baseline HbA1c 7.9 ± 1.9%, with prior GLP-1 RA use 24.1%, and concomitant SGLT2i intake (41.4%) were included. During a median follow-up of 6 months, the mean serum HbA1c level reduction was 1.3 ± 1.7% with weight loss of 4.7 ± 4.1 kg. The proportion of patients who achieved optimal and sustainable glycemic control (HbA1c &lt;7.0%) increased from 43.1% to 55.8% at the last follow-up. The proportion of patients reaching both HbA1c targets of &lt;7.0% and 5% weight loss was 27.8%. No cases of pancreatitis, cancer, or progressive retinopathy were observed.</p><p><strong>Conclusions</strong>. In this single center undertaking, it was shown that in among persons with T2DM and obesity in Thailand, semaglutide was associated with short-term glycemic control and weight loss comparable with what has been observed in randomized clinical trials and other RWE.</p> ER -