Pituitary Abscess Mimicking a Pituitary Adenoma Presenting with Secondary Amenorrhea and Blurring of Vision

Jerico Gutierrez, Mark Anthony Sandoval, Daryl Jade Dagang, Kathleen Joy Khu

Abstract

Pituitary abscess is a rare condition. It can present with hormonal deficiencies and may affect reproductive health. We present a case of a 43-year-old female presenting with bitemporal hemianopsia and amenorrhea. Imaging of the pituitary showed a sellar-suprasellar mass 2.6 x 2.4 x 1.8 cm with an enhancing nodular component. Pre-operative diagnosis was pituitary adenoma with panhypopituitarism and compression of the optic chiasm. The patient underwent transsphenoidal excision of the tumor. Intraoperative findings revealed purulent fluid consistent with pituitary abscess. There was immediate improvement of vision post operatively. She did not develop diabetes insipidus. Gram stain showed polymorphonuclear (PMN) cells 0-1 per oil immersion field (OIF) and Gram-positive cocci 0-1 per OFI, however there was no growth on culture. The abscess was also negative for acid-fast bacilli and was negative on polymerase chain reaction. Histopathologic evaluation showed benign cyst contents. The patient was treated with ceftriaxone 2 grams every 12 hours for 14 days and was eventually discharged with prednisone and levothyroxine. Pituitary abscess is an important differential diagnosis for sellar and suprasellar masses. There are no specific clinical and radiologic features that will enable a

Keywords

pituitary abscess, amenorrhea, blurring of vision

Full Text:

Abstract HTML PDF

References

Hanel RA, Koerbel A, Prevedello DM, Moro MS, Araújo JC. Primary pituitary abscess: Case report. Arq Neuropsiquiatr. 2002;60(3-B):861-5. PMID: 12364963. https://doi.org/10.1590/S0004-282X2002000500033.

Ciappetta P, Calace A, D’ Urso PI, De Candia N. Endoscopic treatment of pituitary abscess: Two case reports and literature review. Neurosurg Rev. 2008;31(2):237–46. PMID: 17899232. https://doi.org/10.1007/s10143-007-0096-2.

Dutta P, Bhansali A, Singh P, Kotwal N, Pathak A, Kumar Y. Pituitary abscess: Report of four cases and review of literature. Pituitary. 2006;9(3): 267–73. PMID: 16845602. https://doi.org/10.1007/s11102-006-8327-z.

Jain KC, Varma A, Mahapatra AK. Pituitary abscess: A series of six cases. Br J Neurosurg. 1997;11(2):139-43. PMID: 9156001. https://doi.org/10.1080/02688699746492.

Liu F, Li G, Yao Y, Yang Y, Ma W, Li Y, et al. Diagnosis and management of pituitary abscess: Experiences from 33 cases. Clin Endocrinol (Oxf). 2011;74(1):79–88.PMID: 21039726. https://doi.org/ 10.1111/j.1365-2265.2010.03890.x.

Vates GE, Berger MS, Wilson CB. Diagnosis and management of pituitary abscess: A review of twenty-four cases. J Neurosurg. 2001;95(2):233–41. PMID: 11780892. https://doi.org/ 10.3171/jns.2001.95.2.0233.

Lemoncito MV, Lantion-Ang FL. Pituitary abscess mimicking pituitary adenoma: A review of three cases seen at the Philippine General Hospital from 2004-2007. Philipp J Intern Med. 2009;47(3):143-50.

https://www.pcp.org.ph/documents/PJIM/Volume%2047%20(2009)/Number%203%20(May-June)/8-Pituitary%20Abscess.pdf