Concurrence of Myasthenia Gravis and Thyroid Disorders

A Retrospective Database Study


  • Sasivimol Virameteekul Khon Kaen University, Khon Kaen
  • Suranut Charoensri Khon Kaen University, Khon Kaen
  • Kittisak Sawanyawisuth Khon Kaen University, Khon Kaen
  • Somsak Tiamkao Khon Kaen University, Khon Kaen



autoimmune thyroid diseases, prevalence, treatment


Introduction. Both myasthenia gravis (MG) and autoimmune thyroid diseases (AITDs) are autoimmune diseases. Graves’disease (GD) is the most common AITD reported to be associated with MG. Currently, there is limited data on prevalence and clinical features/outcomes of MG in various thyroid diseases in a large database report.

Methodology. A total of 872 patients with MG and 97,251 patients with thyroid disorders had been recorded by the tertiary hospital database. The study period was between 1997 and 2017. Patients with a thyroid disorder and MG were identified by the ICD-10-CM code. Clinical courses of MG accompanied by thyroid disorders were studied.

Results. During the 20-year study period, there were 872 patients with MG and 97,251 patients with thyroid disorders. In the group with thyroid disorders, 28,886 patients (29.70%) had GD, 1,612 patients (1.66%) had Hashimoto’s thyroiditis, 13,172 patients (13.54%) had toxic goiter and 53,581 patients (55.10%) had nontoxic goiter. 97 patients had been diagnosed with both MG and thyroid disorders. Among the four types of thyroid disorders, the rate of MG was highest in HT group (9.92/1,000 HT patients). There were four significant factors among four groups of thyroid disorders including age of onset of thyroid disease (p 0.004), MG classification (ppp 0.034). Among the four groups of thyroid disorders, patients with MG and HT were diagnosed with thyroid disease at the youngest age (27 years) compared with other thyroid diseases. Additionally, the MG patients with HT also had the highest proportion of MG class 4-5 a/b (7 patients, 43.75%), received prednisolone treatment (15 patients, 93.75%), received immunosuppressants (9 patients, 56.25%), received IVIG or PLEX (5 patients, 31.30%), and had thymoma (6 patients, 46.15%).

Conclusion. MG is most prevalent in patients with HT. Patients with both MG and HT had more severe MG status and had higher rate of thymoma.


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Author Biographies

Sasivimol Virameteekul, Khon Kaen University, Khon Kaen

Medical Resident

Division of Neurology, Department of Medicine, Faculty of Medicine

Neuroscience Research and Development Group

Suranut Charoensri, Khon Kaen University, Khon Kaen

Clinical instructor

Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine

Kittisak Sawanyawisuth, Khon Kaen University, Khon Kaen


Division of Ambulatory Medicine, Department of Medicine, Faculty of Medicine, Sleep Apnea Research Group, Research Center in Back, Neck and other Joint abd Human Performance, Research and Training Center for Enhancing Qulaity of Life of Working Age People, and Research and Diagnostic Center for Emerging Infectious Disease (RCEID)

Somsak Tiamkao, Khon Kaen University, Khon Kaen

Associate Professor

Division of Neurology, Department of Medicine, Faculty of Medicine

Integrated Epilepsy Research Group


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How to Cite

Virameteekul, S., Charoensri, S., Sawanyawisuth, K., & Tiamkao, S. (2019). Concurrence of Myasthenia Gravis and Thyroid Disorders : A Retrospective Database Study. Journal of the ASEAN Federation of Endocrine Societies, 34(2), 153–157.



Original Articles