Association of 25(OH)D Serum Concentrations on Health-Related Quality of Life among Patients with Low Vitamin D
Keywords:vitamin D, 25(OH)D, health-related quality of life
Abstract*Visual Abstracts prepared by Dr. Francis Xavier Mislang
Objective. To determine the association between 25-hydroxyvitamin D [25(OH)D] serum concentrations and health-related quality of life (HRQoL) among patients with low vitamin D levels.
Methodology. This prospective cohort study included 76 patients (ages 18 to 59; 54 females and 22 males) who had baseline 25(OH)D below 30 ng/ml and were prescribed a Vitamin D supplement for eight weeks. HRQoL was assessed at baseline and after 8 weeks through the Functional Assessment of Non-Life Threatening Conditions (FANLTC) questionnaire.
Results. HRQoL of the participants who were Vitamin D deficient and insufficient at baseline were basically the same (p-values >0.05). After supplementation, the personal well-being and overall HRQoL of the participants who were Vitamin D sufficient were significantly higher than those who were Vitamin D deficient or insufficient (p-values < 0.05). Moreover, after supplementation, all the HRQoL subscale scores as well as the total HRQoL scores of the participants were significantly higher than their baseline HRQoL scores (p-values < 0.05).
Conclusion. The improved HRQoL scores after Vitamin D supplementation showed that there is a significant association between 25(OH)D serum concentrations and HRQoL.
Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. The American Journal of Clinical Nutrition. 2004; 80(6): 1678S-1688S.
Mead MN. Benefits of sunlight: A bright spot for human health. Environmental Health Perspectives. 2008; 116(4):A160.
International Osteoporosis Foundation. Widespread vitamin D deficiency a concern in Asia. Science Daily. 13 December 2010. www.sciencedaily.com/releases/2010/12/101213101814.htm
Kennel KA, Drake MT and Hurley DL. Vitamin D deficiency in adults: When to test and how to treat. Mayo Clinic Proceedings. Elsevier. 2010; 85 (8):752-758.
Gröber U, Spitz J, Reichrath J, et al. Vitamin D―Update 2013: From rickets prophylaxis to general preventive healthcare. Dermato-Endocrinology. 2013 Jun;5(3):331-347.
Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society clinical practice guideline. The Journal of Clinical Endocrinology & Metabolism. 2011; 96(7): 1911-1930.
Webster K, David C and Yost K. The Functional Assessment of Chronic Illness Therapy (FACIT) measurement system: Properties, applications, and interpretation. Health and Quality of Life Outcomes 1. 2003; 1: 79.
Iwuagwu OC, et al. Randomized clinical trial examining psychosocial and quality of life benefits of bilateral breast reduction surgery. British Journal of Surgery. 2006; 93(3): 291-294.
FACIT measurement system: Functional Assessment of Non-Life Threatening Conditions (FANLTC) questionnaire. http://www.facit.org/FACITOrg/Questionnaires. Accessed Oct 11, 2011.
Pathak S, Nisar MA, Rosenthal DS. Vitamin D Deficiency (VDD) and Major Depressive Disorder (MDD): A causal or casual association? Paper presented at The Endocrine Society’s 94th Annual Meeting; June 23-26, 2012; Houston, TX. http://www.endocrineweb.com/ professional/meetings/what-role-does-vitamin-d-deficiency-play-depression-small-case-study-report. Accessed Aug 11, 2012.
Huang W, Shah S, Long Q, Crankshow AK, Tangpricha V, Improvement of pain, sleep and quality of life in chronic pain patients with vitamin D supplementation. Clin J Pain. 2013 Apr; 29(4):341-7.
Yang L, et al. Therapeutic effect of vitamin D supplementation in a pilot study of Crohn’s patients. Clin Transl Gastroenterol. 2013; 4:e33.
How to Cite
Journal of the ASEAN Federation of Endocrine Societies is licensed under a Creative Commons Attribution-NonCommercial 4.0 International. (full license at this link: http://creativecommons.org/licenses/by-nc/3.0/legalcode).
To obtain permission to translate/reproduce or download articles or use images FOR COMMERCIAL REUSE/BUSINESS PURPOSES from the Journal of the ASEAN Federation of Endocrine Societies, kindly fill in the Permission Request for Use of Copyrighted Material and return as PDF file to email@example.com or firstname.lastname@example.org.
A written agreement shall be emailed to the requester should permission be granted.