The Association Between Serum 25-hydroxyvitamin D and Glycemic Control in Patients With Diabetes Mellitus

A Single-Center Retrospective Study




KEYWORDS: Vitamin D, serum 25(OH)D, diabetes mellitus, glycemic control


Objective. To determine the association between serum 25-hydroxyvitamin D (25(OH)D) and measures of glycemic control, hemoglobin A1c (HbA1c) and fasting plasma glucose (FPG), in adult patients with diabetes mellitus.

Methodology. This is an analytical cross-sectional study of 270 patients with diabetes admitted to a tertiary hospital. Serum 25(OH)D levels were categorized as follows: sufficient (>30 ng/mL), insufficient (20 to 30 ng/mL), and deficient (<20 ng/mL). The correlation of HbA1c and FPG with serum 25(OH)D and other variables was determined using Spearman’s rho (ρ) coefficient. The risk factors associated with HbA1c ≥7% and FPG ≥126 mg/dL were determined using logistic regression analysis to generate crude and adjusted odds ratios. The null hypothesis was rejected at 0.05 α-level of significance.

Results. The median serum 25(OH)D was 18.92 (range 3.56–56.3) ng/mL. Ninety percent (245 patients) had vitamin D levels below 30 ng/mL. This study showed that vitamin D level is significantly but weakly correlated with patient’s age (ρ=0.339) and duration of diabetes (ρ=0.147), whereas it had inverse correlations with BMI (ρ=-0.134), HbA1c (ρ=-0.261), and FPG (ρ=-0.198).

Conclusion. In this study, we found a possible association between vitamin D levels and measures of glycemic control among this group of adult Filipino patients with diabetes mellitus, but further investigations in other cohorts of individuals with diabetes are needed.


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Author Biographies

Mariel Enverga, Makati Medical Center, Makati City, Philippines

Section of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine

Maria Jocelyn Isidro, Makati Medical Center, Makati City, Philippines

Section of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine

St. Luke’s Medical Center- Global City, Taguig, Philippines

St. Clare’s Medical Center, Palanan, Makati City, Philippines

Nerissa Ang-Golangco, Makati Medical Center, Makati City, Philippines

Section of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine

St. Clare’s Medical Center, Palanan, Makati City, Philippines

Adventist Medical Center, Pasay City, Philippines


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How to Cite

Enverga, M., Isidro, M. J., & Ang-Golangco, N. . (2022). The Association Between Serum 25-hydroxyvitamin D and Glycemic Control in Patients With Diabetes Mellitus: A Single-Center Retrospective Study. Journal of the ASEAN Federation of Endocrine Societies, 38(1), 13–20.



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