THE DIFFERENCES IN INTERLEUKIN-6 LEVELS AND MEAN PLATELET VOLUME BETWEEN NON-ALCOHOLIC FATTY LIVER DISEASE AND NON NAFLD GROUPS IN YOUNG SUBJECTS WITH CENTRAL OBESITY

Authors

  • Nancy Lestari Department of Internal Medicine, Sam Ratulangi University, Manado, North Sulawesi, Indonesia
  • Linda Rotty Department of Internal Medicine, Hematology Oncology Medic Division, Sam Ratulangi University, Manado, North Sulawesi, Indonesia
  • Nelly Tendean Department of Internal Medicine, Gastroenterology Hepatology Division, Sam Ratulangi University, Manado, North Sulawesi, Indonesia
  • Frans Wantania Department of Internal Medicine, Cardiology Division, Sam Ratulangi University, Manado, North Sulawesi, Indonesia
  • Jonathan Arifputra Department of Internal Medicine, Sam Ratulangi University, Manado, North Sulawesi, Indonesia

Keywords:

central obesity, NAFLD, IL-6, MPV

Abstract

INTRODUCTION
Obesity is one of the major risk factors of metabolic diseases such as NAFLD. Proinflammatory cytokines played specific role in the incidence of NAFLD. IL-6 influences megakaryocyte maturation and platelet size, which is measured as mean platelet volume (MPV). The purpose was to determine the difference in IL-6 and MPV levels between NAFLD and non NAFLD groups in central obesity.

METHODOLOGY
This research was a comparative analytic with cross sectional study conducted in May 2018 - July 2018. Samples were taken sequentially based on inclusion criteria. Serum IL-6 was examined by ELISA, reagent kit R&D System Inc. MPV was examined by Sysmex XN-2000-1-flR. NAFLD was diagnosed by abdominal ultrasound.

RESULTS
This study included 40 samples, with mean age 30±5 years old, including 28 people (70%) who experienced NAFLD. Subjects had mean waist circumference of 99.08±8.42 cm and mean BMI of 28.35±3.59 cm. The difference in mean IL-6 levels between NAFLD and non NAFLD groups was 2.27±1.08 pg/mL vs 1.21±0.25 pg/mL (p = 0.002). While the mean difference in MPV in the NAFLD and non-NAFLD groups was 10.19±0.82 fL vs 9.39±0.66 fL (p = 0.005). IL-6 plays an important role in the acute inflammatory response, include inducing liver to synthesize other inflammatory mediators. IL-6 affects the maturation of megakaryocytes, causing larger platelets to be released into the blood circulation.

CONCLUSION
There was a significant difference between IL-6 and MPV levels in NAFLD group compared with non NAFLD group in central obesity.

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Published

2022-06-07

How to Cite

Lestari, N., Rotty, L., Tendean, N., Wantania, F., & Arifputra, J. (2022). THE DIFFERENCES IN INTERLEUKIN-6 LEVELS AND MEAN PLATELET VOLUME BETWEEN NON-ALCOHOLIC FATTY LIVER DISEASE AND NON NAFLD GROUPS IN YOUNG SUBJECTS WITH CENTRAL OBESITY. Journal of the ASEAN Federation of Endocrine Societies, 34(2), 43. Retrieved from https://www.asean-endocrinejournal.org/index.php/JAFES/article/view/2005

Issue

Vol. 34 No. 2 (2019): AFES Book of Abstracts (Supplement)

Section

Abstracts of Original Articles | General Endocrinology

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