Corneal Confocal Microscopy Identifies Structural Small Fibre Abnormalities in an Adolescent with Type 1 Diabetes and Impaired Awareness of Hypoglycaemia

Mainak Banerjee; Pradip Mukhopadhyay; Madhurima Basu; Sujoy Ghosh

doi:10.15605/jafes.038.02.21

Authors

Mainak Banerjee Institute of Post Graduate Medical Education and Research, Kolkata, India https://orcid.org/0000-0002-6656-8569
Pradip Mukhopadhyay Institute of Post Graduate Medical Education and Research, Kolkata, India https://orcid.org/0000-0002-4580-9589
Madhurima Basu Institute of Post Graduate Medical Education and Research, Kolkata, India https://orcid.org/0000-0003-4693-5795
Sujoy Ghosh Institute of Post Graduate Medical Education and Research, Kolkata, India https://orcid.org/0000-0001-5397-961X

DOI:

https://doi.org/10.15605/jafes.038.02.21

Keywords:

corneal confocal microscopy, small fibre, autonomic neuropathy, hypoglycaemia, T1DM

Abstract

Impaired awareness of hypoglycaemia (IAH) is present in around 25-40% of individuals with type 1 diabetes mellitus (T1DM). Herein, we present a case of an adolescent with T1DM and IAH who had worse corneal nerve parameters compared to a T1DM adolescent without IAH. Small fibre abnormalities detected by corneal confocal microscopy in an objective easy-to-perform non-invasive test might be a surrogate indicator of underlying autonomic dysfunction in T1DM and IAH.

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Author Biographies

Mainak Banerjee, Institute of Post Graduate Medical Education and Research, Kolkata, India

Department of Endocrinology

Pradip Mukhopadhyay, Institute of Post Graduate Medical Education and Research, Kolkata, India

Department of Endocrinology

Madhurima Basu, Institute of Post Graduate Medical Education and Research, Kolkata, India

Department of Endocrinology

Sujoy Ghosh, Institute of Post Graduate Medical Education and Research, Kolkata, India

Department of Endocrinology

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