Comparison of the Clinical and Biochemical Profile of Metabolic Syndrome Between Obese Children Below and Above 10-Years Old Attending Paediatric Clinic Hospital Universiti Sains Malaysia from 2006 to 2015

  • Suhaimi Hussain Paediatric Department Hospital University Science Malaysia, School of Medical Sciences 16150 Kota Bharu Kelantan Malaysia http://orcid.org/0000-0002-7164-3076
  • Khoo Kay Men Universiti of Sains Malaysia Department of Paediatrics, School of Medical Sciences, 16150 Kubang Kerian, Kelantan
  • Noorizan Abd Majid Universiti of Sains Malaysia Department of Paediatrics, School of Medical Sciences, 16150 Kubang Kerian, Kelantan
Keywords: obesity, metabolic syndrome, children, pediatric

Abstract

Objective. We aim to compare the clinical and biochemical profile of metabolic syndrome between obese children below and above 10 years attending Paediatric clinic Hospital Universiti Sains Malaysia (HUSM) from 2006 to 2015. This is to determine if age, particularly the transition to puberty, modifies the prevalence of components of metabolic syndrome in obese children.

Methodology. The medical records of 84 obese children under 18 years of age seen at Paediatric clinic HUSM from 2006 to 2015 were reviewed. Demographic (age, gender, ethnicity), anthropometric (weight and height), clinical [body mass index (BMI), systolic blood pressure (SBP) and diastolic blood pressure (DBP)] and biochemical [serum total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), fasting plasma glucose (FPG)] parameters were recorded, analyzed and compared.

Results. Majority of subjects in both age groups were boys, with 68.2% <10 years old. Mean age was 9.69 years (±3.36). The clinical and biochemical parameters of metabolic syndrome were similar between those <10 years old and >10 years, with the exception of BMI, waist circumference, SBP and TG level. Multivariate regression analysis showed that the parameters of metabolic syndrome significantly associated with age ≥10 years were systolic hypertension (adjusted OR 7.17, 95% CI, 1.48 to 34.8) and BMI >30 kg/m2 (adjusted OR 3.02, 95% CI, 1.16 to 7.86).

Conclusion. There were similar clinical and biochemical parameters of metabolic syndrome in both age groups. The proportions of children with metabolic syndrome were similar regardless of age group. The overall prevalence rate of metabolic syndrome was 27.3%. In view of the alarming presence of components of metabolic syndrome even in children less than 10 years of age, efforts aimed at the prevention of childhood obesity in the community should be intensified.

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Author Biography

Suhaimi Hussain, Paediatric Department Hospital University Science Malaysia, School of Medical Sciences 16150 Kota Bharu Kelantan Malaysia

Paediatric Department

Senior Lecturer, Paediatrician, Paediatric Endocrinologist

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Published
2017-10-14
How to Cite
Hussain, S., Men, K. K., & Majid, N. A. (2017). Comparison of the Clinical and Biochemical Profile of Metabolic Syndrome Between Obese Children Below and Above 10-Years Old Attending Paediatric Clinic Hospital Universiti Sains Malaysia from 2006 to 2015. Journal of the ASEAN Federation of Endocrine Societies, 32(2), 132. Retrieved from https://www.asean-endocrinejournal.org/index.php/JAFES/article/view/415
Section
Original Articles