Aplasia Cutis Congenita on the Scalp

Supasuta Wongdama; Chutintorn Sriphrapradang

doi:10.15605/jafes.040.01.11

Authors

Supasuta Wongdama Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand https://orcid.org/0000-0001-7787-8231
Chutintorn Sriphrapradang Faculty of Medicine Ramathibodi Hospital, Mahidol University https://orcid.org/0000-0001-8294-8601

DOI:

https://doi.org/10.15605/jafes.040.01.11

Keywords:

ectodermal dysplasia, fetal diseases, Graves' disease, methimazole, pregnancy

Abstract

Aplasia cutis congenita is a rare condition characterized by localized absent skin at birth, often affecting the scalp. The exact pathogenesis is unclear, but it is likely related to disrupted prenatal skin development. Potential etiologies include genetic factors, trauma, intrauterine infections, teratogens, incomplete neural tube closure, and vascular compromise. We present a case of aplasia cutis congenita on the scalp potentially associated with maternal methimazole use.

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Author Biographies

Supasuta Wongdama, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

Chutintorn Sriphrapradang, Faculty of Medicine Ramathibodi Hospital, Mahidol University

Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

References

1. Alexander EK, Pearce EN, Brent GA, et al. 2017 Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and the postpartum. Thyroid. 2017;27(3):315-89. https://pubmed.ncbi.nlm.nih.gov/28056690. https://doi.org/10.1089/thy.2016.0457. DOI: https://doi.org/10.1089/thy.2017.0155

2. Kobaly K, Mandel SJ. Hyperthyroidism and pregnancy. Endocrinol Metab Clin North Am. 2019;48(3):533-45. https://pubmed.ncbi.nlm.nih.gov/3134552 https://doi.org/10.1016/ DOI: https://doi.org/10.1016/j.ecl.2019.05.002

j.ecl.2019.05.002. DOI: https://doi.org/10.1088/1475-7516/2019/05/002

3. Agrawal M, Lewis S, Premawardhana L, Dayan CM, Taylor PN, Okosieme OE. Antithyroid drug therapy in pregnancy and risk of congenital anomalies: Systematic review and meta-analysis. Clin Endocrinol (Oxf). 2022;96(6):857-68. https://pubmed.ncbi.nlm.nih.gov/34845757 https://doi.org/10.1111/ DOI: https://doi.org/10.1111/cen.14646

cen.14646.