A Case of Retroperitoneal Liposarcoma Mimicking an Adrenocortical Carcinoma

Authors

DOI:

https://doi.org/10.15605/jafes.034.01.15

Keywords:

Adrenal pseudotumours, adrenal mass, dedifferentiated liposarcoma

Abstract

An adrenal mass can be a diagnostic challenge as it is not easy to differentiate the adrenal glands from other adrenal pseudotumours with only radio-imaging. We report a 28-year-old patient who was diagnosed radiologically as an adrenal cortical carcinoma after he presented with abdominal pain and fullness. Biochemically, he demonstrated secondary hyperaldosteronism. Intra-operatively there was a huge mass, inferior to a normal right adrenal, which was histopathologically proven to be a dedifferentiated liposarcoma.

Downloads

Download data is not yet available.

Author Biographies

Waye Kang, University Tunku Abdul Rahman

Lecturer,

Department of Medicine

Carolina Singarayar, Ministry of Health, Malaysia

Endocrinology Fellow, Universiti Kebangsaan Malaysia

Norasyikin Abdul Wahab, Universiti Kebangsaan Malaysia

Associate Professor in Medicine,

Department of Medicine

Norlela Sukor, Universiti Kebangsaan Malaysia

Professor in Medicine,

Department of Medicine

Nor Azmi Kamaruddin, Universiti Kebangsaan Malaysia

Professor in Medicine,

Department in Medicine

References

Parnaby CN, Chong PS, Chisholm L, Farrow J, Connell JM, O’Dwyer PJ. The role of laparoscopic adrenalectomy for adrenal tumours of 6 cm or greater. Surg Endosc. 2008;22(3):617-21. PMID: 18071798. https://doi.org/10.1007/s00464-007-9709-7.

Liao CH, Chueh SC, Lai MK, Hsiao PJ, Chen J. Laparoscopic adrenalectomy for potentially malignant adrenal tumors greater than 5 centimeters. J Clin Endocrinol Metab. 2006;91(8):3080-3. PMID: 16720665. https://doi.org/10.1210/jc.2005-2420.

Zografos GN, Farfaras A, Vasiliadis G, et al. Laparoscopic resection of large adrenal tumors. JSLS. 2010;14(3):364-8. PMID: 21333189. PMCID: PMC3041032.https://doi.org/10.4293/108680810X12924466007160.

Mege D, Taieb D, Lowery A, et al. Contemporary review of large adrenal tumors in a tertiary referral center. Anticancer Res. 2014;34(5):2581-8. PMID: 24778080.

Kerkhofs TM, Roumen RM, Demeyere TB, van der Linden AN, Haak HR. Adrenal tumors with unexpected outcome: A review of the literature. Int J Endocrinol. 2015;2015:710514. PMID: 25883649. PMCID: PMC4389822. https://doi.org/10.1155/2015/710514.

Crago AM, Singer S. Clinical and molecular approaches to well-differentiated and dedifferentiated liposarcoma. Curr Opin Oncol. 2011;23(4):373-8. PMID: 21552124. PMCID: PMC3253354. https://doi.org/10.1097/CCO.0b013e32834796e6.

Dalal KM, Kattan MW, Antonescu CR, Brennan MF, Singer S. Subtype specific prognostic nomogram for patients with primary liposarcoma of the retroperitoneum, extremity, or trunk. Ann Surg. 2006;244(3):381-91. PMID: 16926564. PMCID: PMC1856537. https://doi.org/10.1097/01.sla.0000234795.98607.00.

Fletcher CD, Akerman M, Dal Cin P, et al. Correlation between clinicopathological features and karyotype in lipomatous tumors. A report of 178 cases from the Chromosomes and Morphology (CHAMP) Collaborative Study Group. Am J Pathol. 1996;148(2):623-30. PMID: 8579124. PMCID: PMC1861666.

Meis-Kindblom J, Sjögren H, Kindblom LG, et al. Cytogenetic and molecular genetic analyses of liposarcoma and its soft tissue simulators: Recognition of new variants and differential diagnosis. Virchows Arch. 2001;439(2):141-51. PMID: 11561754. https://doi.org/10.1007/s004280100423.

Coindre JM, Pédeutour F, Aurias A. Well-differentiated and dedifferentiated liposarcomas. Virchows Arch. 2010;456(2):167-79. PMID: 19688222. https://doi.org/ 10.1007/s00428-009-0815-x.

Oliner JD, Kinzler KW, Meltzer PS, George DL, Vogelstein B. Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature. 1992;358(6381):80-3. PMID: 1614537. https://doi.org/10.1038/358080a0.

Oliner JD, Pietenpol JA, Thiagalingam S, Gyuris J, Kinzler KW, Vogelstein B. Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53. Nature. 1993;362(6423):857-60. PMID: 8479525. https://doi.org/10.1038/362857a0.

Ortega S, Malumbres M, Barbacid M. Cyclin D-dependent kinases, INK4 inhibitors and cancer. Biochim Biophys Acta. 2002;1602(1):73-87. PMID: 11960696. https://doi.org/10.1016/S0304-419X(02)00037-9.

Singer S, Antonescu CR, Riedel E, Brennan MF. Histologic subtype and margin of resection predict pattern of recurrence and survival for retroperitoneal liposarcoma. Ann Surg. 2003;238(3):358-70. PMID: 14501502. PMCID: PMC1422708. https://doi.org/ 10.1097/01.sla.0000086542.11899.38.

Murphey MD, Arcara LK, Fanburg-Smith J. From the archives of the AFIP: Imaging of musculoskeletal liposarcoma with radiologic-pathologic correlation. Radiographics. 2005;25(5):1371-95. PMID: 16160117. https://doi.org/10.1148/rg.255055106.

Binh MBN, Sastre-Garau X, Guillou L, et al. MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: A comparative analysis of 559 soft tissue neoplasms with genetic data. 2005;29(10):1340-7. PMID: 16160477.

Published

2019-07-30

How to Cite

Kang, W., Singarayar, C., Abdul Wahab, N., Sukor, N., & Kamaruddin, N. A. (2019). A Case of Retroperitoneal Liposarcoma Mimicking an Adrenocortical Carcinoma. Journal of the ASEAN Federation of Endocrine Societies, 34(1), 95. https://doi.org/10.15605/jafes.034.01.15

Issue

Section

Case Reports

Most read articles by the same author(s)

1 2 > >>