Papillary Mucinous Neoplasm of the Pancreas Presenting as Worsening Hyperglycemia in a 72-Year-Old Patient with Type 2 Diabetes
DOI:
https://doi.org/10.15605/jafes.041.01.5251Keywords:
intraductal papillary mucinous neoplasm (IPMN), worsening glycemic controlAbstract
Pancreatic cysts are common findings encountered and increasingly detected through cross-sectional imaging. Intraductal papillary mucinous neoplasm (IPMN) is the most common pancreatic cystic neoplasms and may be macroscopic precursor of pancreatic ductal adenocarcinoma. 1 New-onset diabetes or worsening glycemic control may serve as clinical clues to underlying pancreatic neoplasia.2 We present an interesting case of worsening glycemic control in a patient with long-standing type 2 diabetes (T2D) as the first manifestation of IPMN with high-grade dysplasia.
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1. Gonda TA, Cahen DL, Farrell JJ. Pancreatic Cysts. N Engl J Med. 2024;391(9):832-43. https://pubmed.ncbi.nlm.nih.gov/39231345 https://doi.org/10.1056/NEJMra2309041
2. Liu J, Knezetic JA, Strömmer L, Permert J, Larsson J, Adrian TE. The intracellular mechanism of insulin resistance in pancreatic cancer patients. J Clin Endocrinol Metab. 2000;85(3):1232-8. https://pubmed.ncbi.nlm.nih.gov/10720068 https://doi.org/10.1210/jcem.85.3.6400
3. Frank RC, Shim B, Lo T, et al. Pancreatic cancer screening in new-onset and deteriorating diabetes: Preliminary results from the PANDOME study. J Clin Endocrinol Metab. 2025;111(1):e148-55. https://pubmed.ncbi.nlm.nih.gov/40439123 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12712999 https://doi.org/10.1210/clinem/dgaf319
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