Pro12Ala POLYMORPHISM IN THE PPARG GENE IS ASSOCIATED WITH GESTATIONAL DIABETES AMONG FILIPINOS: A CROSS-SECTIONAL STUDY

Authors

  • Maria Ruth Pineda-Cortel Department of Medical Technology, Faculty of Pharmacy, University of Santo Tomas Manila, Philippines
  • Sheena Abad Department of Medical Technology, Faculty of Pharmacy, University of Santo Tomas Manila, Philippines
  • Yvette Bailon Department of Medical Technology, Faculty of Pharmacy, University of Santo Tomas Manila, Philippines
  • Vanessa Mae Bugarin Department of Medical Technology, Faculty of Pharmacy, University of Santo Tomas Manila, Philippines
  • Ryna Zatchel Domingo Department of Medical Technology, Faculty of Pharmacy, University of Santo Tomas Manila, Philippines
  • John Lawrence Fernandez Department of Medical Technology, Faculty of Pharmacy, University of Santo Tomas Manila, Philippines
  • Trisha Claire Mendoza Department of Medical Technology, Faculty of Pharmacy, University of Santo Tomas Manila, Philippines
  • Raphael Enrique Tiongco Department of Medical Technology, College of Allied Medical Professions, Angeles University Foundation, Angeles City, Philippines

Keywords:

gestational diabetes mellitus, rs1801282, pparg, Filipino

Abstract

INTRODUCTION
 In this study, we determined the association between Pro12Ala polymorphism in the PPARG gene with gestational diabetes mellitus (GDM) among Filipinos. The association of the alleles and genotypes of the polymorphism with glycemia and insulin resistance was also determined.

METHODOLOGY
 With ethical clearance, approximately 258 pregnant women (86 with GDM and 172 without GDM) were recruited. Whole blood was collected from each and was used for genomic DNA extraction. Laboratory tests such as oral glucose tolerance test, glycated hemoglobin (HbA1c), and insulin levels were performed. The extracted genomic DNA sample was subjected to allelic discrimination analysis using the TaqMan assay.

CONCLUSION
 Overall, the Pro12Ala polymorphism of the PPARG gene may exhibit a protective role against GDM among selected Filipino women; however, further studies are needed to verify our claims.

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Author Biography

Maria Ruth Pineda-Cortel, Department of Medical Technology, Faculty of Pharmacy, University of Santo Tomas Manila, Philippines

Research Center for the Natural and Applied Sciences, University of Santo Tomas, Manila, Philippines

References

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Published

2022-06-02

How to Cite

Pineda-Cortel, M. R., Abad, S., Bailon, Y., Bugarin, V. M., Domingo, R. Z., Fernandez, J. L., Mendoza, T. C., & Tiongco, R. E. (2022). Pro12Ala POLYMORPHISM IN THE PPARG GENE IS ASSOCIATED WITH GESTATIONAL DIABETES AMONG FILIPINOS: A CROSS-SECTIONAL STUDY. Journal of the ASEAN Federation of Endocrine Societies, 34(2), 33. Retrieved from https://www.asean-endocrinejournal.org/index.php/JAFES/article/view/1973

Issue

Vol. 34 No. 2 (2019): AFES Book of Abstracts (Supplement)

Section

Abstracts of Original Articles | Prediabetes, Diabetes Mellitus, Hypoglycemia

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