Recurrent Syncope, Behavioral Changes and Weight Gain in an Elderly Filipino Woman
Successful Diagnosis and Management of Insulinoma With 13-Year Disease-Free Follow-up
DOI:
https://doi.org/10.15605/jafes.041.02.6285Keywords:
hypoglycemia, insulinoma, pancreatic neoplasms, weight gain, syncope, blood glucoseAbstract
Recurrent syncope and behavioral changes in the older population may suggest several disease entities associated with aging. Hypoglycemia is an often-missed potentially correctable underlying cause that should also be considered in the differential diagnosis. We present a case of a 62-year-old Filipino woman who presented with recurrent syncopal attacks, behavioral changes and unintentional weight gain, associated with endogenous hyperinsulinemic hypoglycemia with no pancreatic mass seen on abdominal CT scan. A pancreatic head tumor was visualized through endoscopic ultrasound. Surgical removal of the mass resulted in resolution of her symptoms and restoration of her physical and functional well-being. This case is being reported to highlight that surgery cured her of the disease and she remains asymptomatic and well 13 years after her surgery.
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1. Vaidakis D, Karoubalis J, Pappa T, Piaditis G, Zografos GN. Pancreatic insulinoma: Current issues and trends. Hepatobiliary Pancreat Dis Int. 2010;9(3):234-41. https://pubmed.ncbi.nlm.nih.gov/20525548
2. Service FJ, McMahon MM, O'Brien PC, Ballard DJ. Functioning insulinoma – incidence, recurrence, and long-term survival of patients: A 60-year study. Mayo Clin Proc. 1991;66(7):711-9. https://pubmed.ncbi.nlm.nih.gov/1677058 DOI: 10.1016/s0025-6196(12)62083-7
3. Boukhman MP, Karam JH, Shaver J, Siperstein AE, Duh QY, Clark OH. Insulinoma – experience from 1950 to 1995. West J Med. 1998;169(2):98-104. https://pubmed.ncbi.nlm.nih.gov/9735690 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1305178
4. Cryer PE, Axelrod L, Grossman AB, et al. Evaluation and management of adult hypoglycemic disorders: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2009;94(3):709-28. https://pubmed.ncbi.nlm.nih.gov/19088155 https://doi.org/10.1210/jc.2008-1410
5. Giannis D, Moris D, Karachaliou GS, et al. Insulinomas: From diagnosis to treatment. A review of the literature. J BUON. 2020;25(3):1302-14. https://pubmed.ncbi.nlm.nih.gov/32862570
6. Christ E, Antwi K, Fani M, Wild D. Innovative imaging of insulinoma: The end of sampling? A review. Endocr Relat Cancer. 2020;27(4):R79-92. https://pubmed.ncbi.nlm.nih.gov/31951592 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040495 https://doi.org/10.1530/ERC-19-0476
7. Alogakos M, Nakanishi H, Athanasiadis DI, et al. Enucleation for insulinoma: Consolidating evidence through systematic review and meta-analysis. Surg Endosc. 2025;39(10):6352-65. https://pubmed.ncbi.nlm.nih.gov/40897878 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12500762 https://doi.org/10.1007/s00464-025-12099-0
8. Topsakal Ş, Yaylalı GF, Yarar Z, et al. Multicenter study on the clinical characteristics, diagnosis, and treatment outcomes of insulinoma: Insights from 15 medical centres. Clin Endocrinol. 2025;103(1):57-65. https://pubmed.ncbi.nlm.nih.gov/40275816 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134450 https://doi.org/10.1111/cen.15255
9. Peltola E, Hannula P, Huhtala H, et al. Long-term morbidity and mortality in patients diagnosed with an insulinoma. Eur J Endocrinol. 2021;185(4):577-586. https://pubmed.ncbi.nlm.nih.gov/34374651 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784472 https://doi.org/10.1530/EJE-21-0230
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Copyright (c) 2026 Edwin Canete, Mark Anthony Sandoval

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